John’s Wort or Rifampin: Avoid concomitant use of omeprazole. Hypomagnesemia and Mineral Metabolism: Reported rarely with prolonged treatment with PPIs.Cyanocobalamin (Vitamin B-12) Deficiency: Daily long-term use (e.g., longer than 3 years) may lead to malabsorption or a deficiency of cyanocobalamin.Interaction with Clopidogrel: Avoid concomitant use of omeprazole.Cutaneous and Systemic Lupus Erythematosus: Mostly cutaneous new onset or exacerbation of existing disease discontinue omeprazole and refer to specialist for evaluation (.Severe Cutaneous Adverse Reactions: Discontinue at the first signs or symptoms of severe cutaneous adverse reactions or other signs of hypersensitivity and consider further evaluation.Bone Fracture: Long-term and multiple daily dose PPI therapy may be associated with an increased risk for osteoporosis-related fractures of the hip, wrist or spine.PPI therapy may be associated with increased risk. Clostridium difficile-Associated Diarrhea:.
Acute Tubulointerstitial Nephritis: Discontinue treatment and evaluate patients.Consider additional follow-up and diagnostic testing. Gastric Malignancy: In adults, symptomatic response does not preclude the presence of gastric malignancy.Reduce the dosage to 10 mg once daily for patients with hepatic impairment (Child Pugh Class A, B, or C) and Asian patients ( ***an additional 4 weeks of treatment may be given if no response if recurrence additional 4 to 8 week courses may be considered. **if ulcer present, continue omeprazole delayed-release capsules 20 mg once daily for an additional 14 days. *if ulcer present, continue omeprazole delayed-release capsules 20 mg once daily for an additional 18 days. Starting dose is 60 mg once daily (varies with individual patient, see full prescribing information) as long as clinically indicated ( See full prescribing information for weight based dosing in pediatric patients Maintenance of Healing of EE due to Acid-Mediated GERD See full prescribing information for weight based dosing in pediatric patients 2 years of age and older ( pylori Eradication to Reduce the Risk of Duodenal Ulcer RecurrenceĢ.1) See full prescribing information for weight based dosing in pediatric patients 2 years of age and older ( 20 mg once daily for 4 weeks some patients may require an additional
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